InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM9

Summary

InnateDB Protein

IDBP-6473.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM9

Protein Name

tripartite motif containing 9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000353561

InnateDB Gene

IDBG-6467 (TRIM9)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000269PubMed:20085810}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20085810}. Cell projection, dendrite {ECO:0000269PubMed:20085810}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle- associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum. {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the affected brain areas in Parkinson disease and dementia with Lewy bodies. {ECO:0000269PubMed:20085810}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030425	dendrite

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR003649 B-box, C-terminal
IPR003961 Fibronectin, type III
IPR011011 Zinc finger, FYVE/PHD-type
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00041
PF01108
PF00097

PRINTS

PIRSF

SMART

SM00336
SM00184
SM00502
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9C026