Version 5.4
Homo sapiens Protein: SULT1C2
Summary
InnateDB Protein IDBP-64930.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SULT1C2
Protein Name sulfotransferase family, cytosolic, 1C, member 2
Synonyms humSULTC2; ST1C1; ST1C2; SULT1C1;
Species Homo sapiens
Ensembl Protein ENSP00000319622
InnateDB Gene IDBG-64928 (SULT1C2)
Protein Structure
UniProt Annotation
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Found in adult stomach, kidney and thyroid gland, and in fetal kidney and liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0009308 amine metabolic process
GO:0044281 small molecule metabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00685
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00338
PhosphoSite PhosphoSite-O00338
TrEMBL
UniProt Splice Variant
Entrez Gene 6819
UniGene Hs.668521
RefSeq NP_789795
HUGO HGNC:11456
OMIM 602385
CCDS CCDS2076
HPRD 03858
IMGT
EMBL AB008164 AC019100 AF026303 AF186251 AF186252 AF186253 AF186254 AF186255 AF186256 AF186258 AF186259 AF186260 AF186261 AF186262 AK313193 BC005353 BT006951 CH471182 U66036
GenPept AAC00409 AAC51285 AAF72799 AAF72800 AAF72801 AAF72802 AAF72803 AAF72804 AAF72805 AAF72806 AAH05353 AAP35597 AAY14790 BAA28346 BAG36010 EAW53889 EAW53890

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca