Version 5.4
Homo sapiens Protein: MAP6
Summary
InnateDB Protein IDBP-64944.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP6
Protein Name microtubule-associated protein 6
Synonyms MTAP6; N-STOP; STOP;
Species Homo sapiens
Ensembl Protein ENSP00000307093
InnateDB Gene IDBG-64942 (MAP6)
Protein Structure
UniProt Annotation
Function Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B. {ECO:0000269PubMed:24357581}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:14692697}. Golgi apparatus {ECO:0000250}. Note=Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS).
Disease Associations
Tissue Specificity Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study). {ECO:0000269PubMed:14692697, ECO:0000269PubMed:16624526}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008017 microtubule binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006810 transport
GO:0032418 lysosome localization
GO:0048813 dendrite morphogenesis
Cellular Component
GO:0005794 Golgi apparatus
GO:0005874 microtubule
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR024963 MAP6/FAM154
PFAM PF05217
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JE9
PhosphoSite PhosphoSite-Q96JE9
TrEMBL
UniProt Splice Variant
Entrez Gene 4135
UniGene Hs.623857
RefSeq NP_149052
HUGO HGNC:6868
OMIM 601783
CCDS CCDS31641
HPRD 15989
IMGT
EMBL AB058781 AK123340 AP001922 BC063860 BC139780 BC150254
GenPept AAH63860 AAI39781 AAI50255 BAB47507 BAC85586

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca