InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SFSWAP

Summary

InnateDB Protein

IDBP-64986.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFSWAP

Protein Name

splicing factor, suppressor of white-apricot homolog (Drosophila)

Synonyms

SFRS8; SWAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000261674

InnateDB Gene

IDBG-64984 (SFSWAP)

Protein Structure

UniProt Annotation

Function

Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269PubMed:8940107}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006376	mRNA splice site selection
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0048025	negative regulation of mRNA splicing, via spliceosome