InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ULK1

Summary

InnateDB Protein

IDBP-65055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ULK1

Protein Name

unc-51-like kinase 1 (C. elegans)

Synonyms

ATG1; ATG1A; hATG1; UNC51; Unc51.1;

Species

Homo sapiens

Ensembl Protein

ENSP00000324560

InnateDB Gene

IDBG-65053 (ULK1)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. {ECO:0000269PubMed:18936157, ECO:0000269PubMed:21460634, ECO:0000269PubMed:21795849}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	75 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0017137	Rab GTPase binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007265	Ras protein signal transduction
GO:0007409	axonogenesis
GO:0008104	protein localization
GO:0009103	lipopolysaccharide biosynthetic process
GO:0010506	regulation of autophagy
GO:0010508	positive regulation of autophagy
GO:0016239	positive regulation of macroautophagy
GO:0021707	cerebellar granule cell differentiation
GO:0021933	radial glia guided migration of cerebellar granule cell
GO:0031102	neuron projection regeneration
GO:0031175	neuron projection development
GO:0031623	receptor internalization
GO:0031669	cellular response to nutrient levels
GO:0042594	response to starvation
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0048671	negative regulation of collateral sprouting
GO:0048675	axon extension
GO:0051386	regulation of neurotrophin TRK receptor signaling pathway

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005829	cytosol
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0034045	pre-autophagosomal structure membrane
GO:0034273	ATG1/UKL1 signaling complex
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0070969	ULK1-ATG13-FIP200 complex

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2
IPR018934 RIO-like kinase
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022708 Serine/threonine-protein kinase, C-terminal

PFAM

PF00069
PF07714
PF06293
PF01163
PF12063

PRINTS

PR00109

PIRSF

PIRSF000580

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References