InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPLD1

Summary

InnateDB Protein

IDBP-65074.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPLD1

Protein Name

glycosylphosphatidylinositol specific phospholipase D1

Synonyms

GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; PLD;

Species

Homo sapiens

Ensembl Protein

ENSP00000230036

InnateDB Gene

IDBG-65072 (GPLD1)

Protein Structure

UniProt Annotation

Function

This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004621	glycosylphosphatidylinositol phospholipase D activity
GO:0004630	phospholipase D activity
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity

Biological Process

GO:0001503	ossification
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0002062	chondrocyte differentiation
GO:0002430	complement receptor mediated signaling pathway
GO:0006507	GPI anchor release
GO:0008285	negative regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0009749	response to glucose
GO:0010595	positive regulation of endothelial cell migration
GO:0010694	positive regulation of alkaline phosphatase activity
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010897	negative regulation of triglyceride catabolic process
GO:0010907	positive regulation of glucose metabolic process
GO:0010983	positive regulation of high-density lipoprotein particle clearance
GO:0032869	cellular response to insulin stimulus
GO:0035690	cellular response to drug
GO:0035701	hematopoietic stem cell migration
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043065	positive regulation of apoptotic process
GO:0045919	positive regulation of cytolysis
GO:0046470	phosphatidylcholine metabolic process
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051047	positive regulation of secretion
GO:0070633	transepithelial transport
GO:0071277	cellular response to calcium ion
GO:0071397	cellular response to cholesterol
GO:0071401	cellular response to triglyceride
GO:0071467	cellular response to pH
GO:0097241	hematopoietic stem cell migration to bone marrow
GO:1900076	regulation of cellular response to insulin stimulus

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0043231	intracellular membrane-bounded organelle