InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RANBP2

Summary

InnateDB Protein

IDBP-65100.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RANBP2

Protein Name

RAN binding protein 2

Synonyms

ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000283195

InnateDB Gene

IDBG-65098 (RANBP2)

Protein Structure

UniProt Annotation

Function

E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. {ECO:0000269PubMed:11792325, ECO:0000269PubMed:12032081, ECO:0000269PubMed:15378033, ECO:0000269PubMed:15931224, ECO:0000269PubMed:22194619}.

Subcellular Localization

Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Detected in diffuse and discrete intranuclear foci. Cytoplasmic filaments.

Disease Associations

Encephalopathy, acute, infection-induced, 3 (IIAE3) [MIM:608033]: A rapidly progressive encephalopathy manifesting in susceptible individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem. {ECO:0000269PubMed:19118815}. Note=The disease is caused by mutations affecting the gene represented in this entry. Mutations in the RANBP2 gene predispose to IIAE3, but by themselves are insufficient to make the phenotype fully penetrant; additional genetic and environmental factors are required (PubMed:19118815). {ECO:0000269PubMed:19118815}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 114 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	114 [view]
Protein-Protein	111 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008536	Ran GTPase binding
GO:0016874	ligase activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0000413	protein peptidyl-prolyl isomerization
GO:0005975	carbohydrate metabolic process
GO:0006457	protein folding
GO:0006606	protein import into nucleus
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0016925	protein sumoylation
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0046907	intracellular transport
GO:0051028	mRNA transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005643	nuclear pore
GO:0005829	cytosol
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0042405	nuclear inclusion body
GO:0044615	nuclear pore nuclear basket

Protein Structure and Domains

PDB ID

InterPro

IPR000156 Ran binding domain
IPR001440 Tetratricopeptide TPR1
IPR001876 Zinc finger, RanBP2-type
IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
IPR022011 Nup358/RanBP2 E3 ligase domain
IPR029000 Cyclophilin-like domain

PFAM