InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RANBP2

Summary

InnateDB Gene

IDBG-65098.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RANBP2

Gene Name

RAN binding protein 2

Synonyms

ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2

Species

Homo sapiens

Ensembl Gene

ENSG00000153201

Encoded Proteins

IDBP-65100

RAN binding protein 2

IDBP-384357

RAN binding protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:108719481-108785811

Strand

Forward strand

Band

q13

Transcripts

ENST00000283195	ENSP00000283195
ENST00000425282	ENSP00000398970
ENST00000495924
ENST00000495506

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 114 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	114 [view]
Protein-Protein	111 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008536	Ran GTPase binding
GO:0016874	ligase activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0000413	protein peptidyl-prolyl isomerization
GO:0005975	carbohydrate metabolic process
GO:0006457	protein folding
GO:0006606	protein import into nucleus
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0016925	protein sumoylation
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0046907	intracellular transport
GO:0051028	mRNA transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005643	nuclear pore
GO:0005829	cytosol
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0042405	nuclear inclusion body
GO:0044615	nuclear pore nuclear basket