Version 5.4
Homo sapiens Protein: RNF38
Summary
InnateDB Protein IDBP-65118.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF38
Protein Name ring finger protein 38
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000259605
InnateDB Gene IDBG-65110 (RNF38)
Protein Structure
UniProt Annotation
Function Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme. {ECO:0000269PubMed:23973461}.
Subcellular Localization Nucleus {ECO:0000269PubMed:23973461}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in testis. {ECO:0000269PubMed:12074600}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008584 male gonad development
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0036126 sperm flagellum
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H0F5
PhosphoSite PhosphoSite-Q9H0F5
TrEMBL
UniProt Splice Variant
Entrez Gene 152006
UniGene Hs.609635
RefSeq NP_073618
HUGO HGNC:18052
OMIM 612488
CCDS CCDS6603
HPRD 11519
IMGT
EMBL AF394047 AK024996 AK093480 AL136817 AL161792 AL354935 BC033786 CH471071
GenPept AAH33786 AAM73697 BAB15050 BAG52726 CAB66751 CAO03540 CAO03541 CAO03553 CAO03554 EAW58305

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca