InnateDB Protein
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IDBP-65120.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RNF38
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Protein Name
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ring finger protein 38
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000335239
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InnateDB Gene
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IDBG-65110 (RNF38)
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Protein Structure
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Function |
Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme. {ECO:0000269PubMed:23973461}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:23973461}.
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Disease Associations |
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Tissue Specificity |
Widely expressed with highest levels in testis. {ECO:0000269PubMed:12074600}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001841
Zinc finger, RING-type
IPR018957
Zinc finger, C3HC4 RING-type
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PFAM |
PF13639
PF14634
PF00097
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H0F5
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PhosphoSite |
PhosphoSite-Q9H0F5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
152006
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UniGene |
Hs.609635
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RefSeq |
NP_919310
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HUGO |
HGNC:18052
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OMIM |
612488
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CCDS |
CCDS6604
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HPRD |
11519
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IMGT |
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EMBL |
AF394047
AK024996
AK093480
AL136817
AL161792
AL354935
BC033786
CH471071
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GenPept |
AAH33786
AAM73697
BAB15050
BAG52726
CAB66751
CAO03540
CAO03541
CAO03553
CAO03554
EAW58305
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