InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GHSR

Summary

InnateDB Protein

IDBP-65131.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GHSR

Protein Name

growth hormone secretagogue receptor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000241256

InnateDB Gene

IDBG-65129 (GHSR)

Protein Structure

UniProt Annotation

Function

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). {ECO:0000269PubMed:10604470, ECO:0000269PubMed:11322507}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Short stature, idiopathic, autosomal (ISSA) [MIM:604271]: A condition defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, genetically relevant population, in the absence of specific causative disorders. {ECO:0000269PubMed:16511605}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Pituitary and hypothalamus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001616	growth hormone secretagogue receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016520	growth hormone-releasing hormone receptor activity
GO:0017046	peptide hormone binding
GO:0042562	hormone binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0008154	actin polymerization or depolymerization
GO:0008343	adult feeding behavior
GO:0009725	response to hormone
GO:0009755	hormone-mediated signaling pathway
GO:0030252	growth hormone secretion
GO:0032094	response to food
GO:0032100	positive regulation of appetite
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032869	cellular response to insulin stimulus
GO:0040018	positive regulation of multicellular organism growth
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process
GO:0043134	regulation of hindgut contraction
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0045923	positive regulation of fatty acid metabolic process
GO:0046676	negative regulation of insulin secretion
GO:0046697	decidualization
GO:0050728	negative regulation of inflammatory response
GO:0051963	regulation of synapse assembly

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003905 Growth hormone secretagogue receptor type 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019427 7TM GPCR, serpentine receptor class w (Srw)

PFAM

PF00001
PF10320
PF10323
PF10324

PRINTS

PR00237
PR01417

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92847