Version 5.4
Homo sapiens Protein: CACNG5
Summary
InnateDB Protein IDBP-65254.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNG5
Protein Name calcium channel, voltage-dependent, gamma subunit 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000303092
InnateDB Gene IDBG-65252 (CACNG5)
Protein Structure
UniProt Annotation
Function Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
GO:0015075 ion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0070588 calcium ion transmembrane transport
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR008368 Voltage-dependent calcium channel, gamma subunit
IPR008369 Voltage-dependent calcium channel, gamma-5 subunit
PFAM PF00822
PF13903
PRINTS PR01792
PR01793
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UF02
PhosphoSite PhosphoSite-Q9UF02
TrEMBL
UniProt Splice Variant
Entrez Gene 27091
UniGene Hs.278907
RefSeq NP_665810
HUGO HGNC:1409
OMIM 606405
CCDS CCDS11665
HPRD 05912
IMGT
EMBL AF142618 AF142619 AF142620 AF142621 AF148220 AF361351 AF458898 AK290171 BC101607 BC101633
GenPept AAF00132 AAF03089 AAI01608 AAI01634 AAL50046 AAM00595 BAF82860

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca