InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLK8

Summary

InnateDB Protein

IDBP-65299.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLK8

Protein Name

kallikrein-related peptidase 8

Synonyms

HNP; NP; NRPN; PRSS19; TADG14;

Species

Homo sapiens

Ensembl Protein

ENSP00000291726

InnateDB Gene

IDBG-65297 (KLK8)

Protein Structure

UniProt Annotation

Function

Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269PubMed:16337200}.

Subcellular Localization

Secreted {ECO:0000269PubMed:17761692}. Cytoplasm {ECO:0000269PubMed:17761692}. Note=Shows a cytoplasmic distribution in the keratinocytes.

Disease Associations

Tissue Specificity

Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes. {ECO:0000269PubMed:11309326, ECO:0000269PubMed:11522960, ECO:0000269PubMed:12147714, ECO:0000269PubMed:17761692}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0007613	memory
GO:0008219	cell death
GO:0009611	response to wounding
GO:0031642	negative regulation of myelination
GO:0043616	keratinocyte proliferation
GO:0048681	negative regulation of axon regeneration
GO:0048812	neuron projection morphogenesis
GO:0050807	regulation of synapse organization