InnateDB Protein
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IDBP-65301.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KLK8
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Protein Name
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kallikrein-related peptidase 8
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Synonyms
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HNP; NP; NRPN; PRSS19; TADG14;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000341555
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InnateDB Gene
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IDBG-65297 (KLK8)
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Protein Structure
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Function |
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269PubMed:16337200}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:17761692}. Cytoplasm {ECO:0000269PubMed:17761692}. Note=Shows a cytoplasmic distribution in the keratinocytes.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes. {ECO:0000269PubMed:11309326, ECO:0000269PubMed:11522960, ECO:0000269PubMed:12147714, ECO:0000269PubMed:17761692}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001254
Peptidase S1
IPR009003
Trypsin-like cysteine/serine peptidase domain
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PFAM |
PF00089
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PRINTS |
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PIRSF |
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SMART |
SM00020
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TIGRFAMs |
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Modification |
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SwissProt |
O60259
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11202
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UniGene |
Hs.104570
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RefSeq |
NP_653089
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HUGO |
HGNC:6369
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OMIM |
605644
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CCDS |
CCDS12814
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HPRD |
05733
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IMGT |
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EMBL |
AB008390
AB008927
AB009849
AB010780
AB012761
AC011473
AC011483
AF055982
AF095742
AF095743
AF243527
AF251125
AY359036
AY563055
AY563056
AY563057
AY563058
AY563059
AY563060
AY563061
AY563062
AY563063
AY563064
AY563065
AY563066
AY563067
BC040887
CH471135
DQ267420
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GenPept |
AAD25979
AAD29574
AAD56050
AAF79144
AAF79145
AAG23254
AAG33361
AAH40887
AAQ89395
AAT76913
AAT76914
AAT76915
AAT76916
AAT76917
AAT76918
AAT76919
AAT76920
AAT76921
AAT76922
AAT76923
AAT76924
AAT76925
AAT76926
AAT76927
AAT76928
AAT76929
AAT76930
AAT76931
AAT76932
AAT76933
AAT76934
AAT76935
AAT76936
AAT76937
AAT76938
ABB83339
BAA28673
BAA28676
BAA82665
BAA82666
BAA88684
EAW71962
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