InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MPP7

Summary

InnateDB Protein

IDBP-65442.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPP7

Protein Name

membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364871

InnateDB Gene

IDBG-65436 (MPP7)

Protein Structure

UniProt Annotation

Function

Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. {ECO:0000269PubMed:17332497}.

Subcellular Localization

Membrane; Peripheral membrane protein. Cell junction, tight junction. Cell junction, adherens junction.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0032947	protein complex scaffold
GO:0035591	signaling adaptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0009967	positive regulation of signal transduction
GO:0030010	establishment of cell polarity
GO:0031334	positive regulation of protein complex assembly
GO:0070830	tight junction assembly
GO:0071896	protein localization to adherens junction

Cellular Component

GO:0005739	mitochondrion
GO:0005912	adherens junction
GO:0005923	tight junction
GO:0030054	cell junction
GO:0097025	MPP7-DLG1-LIN7 complex

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR004172 L27
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR014775 L27, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM