Version 5.4
Homo sapiens Gene: MPP7
Summary
InnateDB Gene IDBG-65436.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPP7
Gene Name membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000150054
Encoded Proteins
IDBP-65438
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
IDBP-65440
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
IDBP-65442
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
IDBP-371198
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
IDBP-811663
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Membrane-associated guanylate kinases (MAGUKs) are important adaptor proteins involved in the assembly of protein complexes at sites of cell-cell contact. They are found in synapses, adherens junctions, and tight junctions. All MAGUKs contain at least 1 PDZ domain, an SH3 domain, and a GUK domain, and many contain 1 or 2 L27 domains, which are involved in multimerization of MAGUKs. MPP7 belongs to the p55 stardust subfamily of MAGUKs, which is named for a Drosophila gene required for establishment of cell polarity in the developing fly embryo (Bohl et al., 2007 [PubMed 17237226]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:28050993-28334486
Strand Reverse strand
Band p12.1
Transcripts
ENST00000375732 ENSP00000364884
ENST00000337532 ENSP00000337907
ENST00000375719 ENSP00000364871
ENST00000441595 ENSP00000398319
ENST00000496637 ENSP00000473899
ENST00000481244
ENST00000474731
ENST00000474682
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0032947 protein complex scaffold
GO:0035591 signaling adaptor activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0009967 positive regulation of signal transduction
GO:0030010 establishment of cell polarity
GO:0031334 positive regulation of protein complex assembly
GO:0070830 tight junction assembly
GO:0071896 protein localization to adherens junction
Cellular Component
GO:0005739 mitochondrion
GO:0005912 adherens junction
GO:0005923 tight junction
GO:0030054 cell junction
GO:0097025 MPP7-DLG1-LIN7 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057440
View Gene Order
ENSBTAG00000017354
Not yet available
Cross-References
SwissProt Q5T2T1
TrEMBL
UniProt Splice Variant
Entrez Gene 143098
UniGene Hs.499159
RefSeq NM_173496 XM_005252367
HUGO HGNC:26542
OMIM 610973
CCDS CCDS7158
HPRD 14733
IMGT
EMBL AK315046 AL355501 AL390866 AL391423 BC038105 CH471072
GenPept AAH38105 BAG37526 CAI12708 CAI12709 CAI13640 CAI13641 CAI17344 CAI17345 EAW86045 EAW86047
RNA Seq Atlas 143098

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca