InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAPRE1

Summary

InnateDB Protein

IDBP-65654.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPRE1

Protein Name

microtubule-associated protein, RP/EB family, member 1

Synonyms

EB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000364721

InnateDB Gene

IDBG-65652 (MAPRE1)

Protein Structure

UniProt Annotation

Function

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration. {ECO:0000269PubMed:12388762, ECO:0000269PubMed:16109370, ECO:0000269PubMed:19632184, ECO:0000269PubMed:21646404}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:10644998}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	54 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008022	protein C-terminus binding
GO:0044822	poly(A) RNA binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0008283	cell proliferation
GO:0031115	negative regulation of microtubule polymerization
GO:0035372	protein localization to microtubule
GO:1903033	positive regulation of microtubule plus-end binding

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005881	cytoplasmic microtubule
GO:0015630	microtubule cytoskeleton
GO:0030981	cortical microtubule cytoskeleton
GO:0031253	cell projection membrane
GO:0035371	microtubule plus-end
GO:0042995	cell projection