InnateDB Protein
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IDBP-65784.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GMNN
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Protein Name
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geminin, DNA replication inhibitor
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000230056
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InnateDB Gene
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IDBG-65780 (GMNN)
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Protein Structure
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Function |
Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Mainly cytoplasmic but can be relocalized to the nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated |
Total |
36
[view]
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Protein-Protein |
35
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR022786
Geminin/Multicilin
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PFAM |
PF07412
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75496
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PhosphoSite |
PhosphoSite-O75496
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TrEMBL |
H7C608
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UniProt Splice Variant |
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Entrez Gene |
51053
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UniGene |
Hs.733142
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RefSeq |
NP_056979
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HUGO |
HGNC:17493
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OMIM |
602842
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CCDS |
CCDS4560
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HPRD |
06783
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IMGT |
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EMBL |
AF067855
AK021685
AL133264
BC005185
BC005389
CH471087
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GenPept |
AAC39787
AAH05185
AAH05389
BAG51040
CAC21511
EAW55465
EAW55466
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