InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NLGN1

Summary

InnateDB Protein

IDBP-65857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLGN1

Protein Name

neuroligin 1

Synonyms

NL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000354541

InnateDB Gene

IDBG-65853 (NLGN1)

Protein Structure

UniProt Annotation

Function

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. {ECO:0000269PubMed:18755801, ECO:0000269PubMed:19926856}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0016787	hydrolase activity
GO:0030165	PDZ domain binding
GO:0042043	neurexin family protein binding
GO:0046983	protein dimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0006605	protein targeting
GO:0007157	heterophilic cell-cell adhesion
GO:0007158	neuron cell-cell adhesion
GO:0007399	nervous system development
GO:0007416	synapse assembly
GO:0008152	metabolic process
GO:0016080	synaptic vesicle targeting
GO:0016339	calcium-dependent cell-cell adhesion
GO:0023041	neuronal signal transduction
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0035418	protein localization to synapse
GO:0045184	establishment of protein localization
GO:0045664	regulation of neuron differentiation
GO:0048789	cytoskeletal matrix organization at active zone
GO:0051260	protein homooligomerization
GO:0051491	positive regulation of filopodium assembly
GO:0051965	positive regulation of synapse assembly
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060999	positive regulation of dendritic spine development
GO:0072553	terminal button organization
GO:0097091	synaptic vesicle clustering
GO:0097104	postsynaptic membrane assembly
GO:0097105	presynaptic membrane assembly
GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097114	N-methyl-D-aspartate receptor clustering
GO:0097115	neurexin clustering
GO:0097119	postsynaptic density protein 95 clustering
GO:0097120	receptor localization to synapse
GO:1900029	positive regulation of ruffle assembly
GO:1900244	positive regulation of synaptic vesicle endocytosis
GO:1902533	positive regulation of intracellular signal transduction
GO:2000302	positive regulation of synaptic vesicle exocytosis
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032433	filopodium tip
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density