InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANKLE2

Summary

InnateDB Protein

IDBP-65915.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANKLE2

Protein Name

ankyrin repeat and LEM domain containing 2

Synonyms

KIAA0692; Lem4; LEMD7;

Species

Homo sapiens

Ensembl Protein

ENSP00000350686

InnateDB Gene

IDBG-65913 (ANKLE2)

Protein Structure

UniProt Annotation

Function

Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. {ECO:0000269PubMed:22770216}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:22770216}; Single-pass type III membrane protein {ECO:0000269PubMed:22770216}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0007084	mitotic nuclear envelope reassembly
GO:0035307	positive regulation of protein dephosphorylation
GO:0042326	negative regulation of phosphorylation
GO:0050790	regulation of catalytic activity