InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAB2

Summary

InnateDB Protein

IDBP-65979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAB2

Protein Name

GRB2-associated binding protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354952

InnateDB Gene

IDBG-65975 (GAB2)

Protein Structure

UniProt Annotation

Function

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269PubMed:15750601, ECO:0000269PubMed:19172738}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19172738}. Cell membrane {ECO:0000269PubMed:19172738}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	49 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0009967	positive regulation of signal transduction
GO:0030316	osteoclast differentiation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043306	positive regulation of mast cell degranulation
GO:0045087	innate immune response
GO:0048015	phosphatidylinositol-mediated signaling