InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GAB2

Summary

InnateDB Gene

IDBG-65975.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAB2

Gene Name

GRB2-associated binding protein 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000033327

Encoded Proteins

IDBP-65979

GRB2-associated binding protein 2

IDBP-65981

GRB2-associated binding protein 2

IDBP-603336

GRB2-associated binding protein 2

IDBP-583667

GRB2-associated binding protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:78215297-78418348

Strand

Reverse strand

Band

q14.1

Transcripts

ENST00000361507	ENSP00000354952
ENST00000340149	ENSP00000343959
ENST00000528329
ENST00000526030
ENST00000528886	ENSP00000433762
ENST00000530915	ENSP00000431868
ENST00000534823

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	49 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0009967	positive regulation of signal transduction
GO:0030316	osteoclast differentiation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043306	positive regulation of mast cell degranulation
GO:0045087	innate immune response
GO:0048015	phosphatidylinositol-mediated signaling