InnateDB Protein
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IDBP-66020.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHFR
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Protein Name
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checkpoint with forkhead and ring finger domains
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000320557
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InnateDB Gene
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IDBG-66018 (CHFR)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. {ECO:0000269PubMed:10935642, ECO:0000269PubMed:11807090, ECO:0000269PubMed:11912157, ECO:0000269PubMed:14562038, ECO:0000269PubMed:14694445, ECO:0000269PubMed:18172500, ECO:0000269PubMed:19182791}.
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Subcellular Localization |
Nucleus, PML body {ECO:0000269PubMed:11912157, ECO:0000269PubMed:15467728, ECO:0000269PubMed:18172500}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:10935642}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
49
[view]
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Protein-Protein |
41
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
8
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001841
Zinc finger, RING-type
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PFAM |
PF13639
PF14634
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q96EP1
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PhosphoSite |
PhosphoSite-Q96EP1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55743
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UniGene |
Hs.720197
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RefSeq |
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HUGO |
HGNC:20455
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OMIM |
605209
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC127070
AF170724
AK001658
AK027687
AK302785
AK304333
AL137561
BC012072
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GenPept |
AAF91084
AAH12072
BAA91817
BAB55297
BAG63989
BAG65178
CAB70812
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