Version 5.4
Homo sapiens Gene: CHFR
Summary
InnateDB Gene IDBG-66018.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHFR
Gene Name checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072609
Encoded Proteins
IDBP-66020
checkpoint with forkhead and ring finger domains
IDBP-66022
checkpoint with forkhead and ring finger domains
IDBP-385341
checkpoint with forkhead and ring finger domains
IDBP-385342
checkpoint with forkhead and ring finger domains
IDBP-385346
checkpoint with forkhead and ring finger domains
IDBP-807679
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
IDBP-807680
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
IDBP-585710
checkpoint with forkhead and ring finger domains
IDBP-585223
checkpoint with forkhead and ring finger domains
IDBP-597286
checkpoint with forkhead and ring finger domains
IDBP-593488
checkpoint with forkhead and ring finger domains
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:132822187-132956304
Strand Reverse strand
Band q24.33
Transcripts
ENST00000315585 ENSP00000320557
ENST00000266880 ENSP00000266880
ENST00000443047 ENSP00000416431
ENST00000450056 ENSP00000398735
ENST00000432561 ENSP00000392395
ENST00000502279
ENST00000511001
ENST00000499045
ENST00000536843
ENST00000545046
ENST00000544268
ENST00000544093 ENSP00000483699
ENST00000535527 ENSP00000478791
ENST00000538235
ENST00000535897
ENST00000541817 ENSP00000445371
ENST00000540963 ENSP00000441837
ENST00000540537 ENSP00000443237
ENST00000542714 ENSP00000443761
ENST00000537551
ENST00000535181
ENST00000536196
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 8 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0000278 mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007067 mitotic nuclear division
GO:0007093 mitotic cell cycle checkpoint
GO:0019941 modification-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0016605 PML body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000014668
View Gene Order
ENSBTAG00000013951
Not yet available
Cross-References
SwissProt Q96EP1
TrEMBL F5H7R8 F5H829 U3KQ08
UniProt Splice Variant
Entrez Gene 55743
UniGene Hs.560002 Hs.619296 Hs.720197
RefSeq NM_001161344 NM_001161345 NM_001161346 NM_001161347 NM_018223
HUGO HGNC:20455
OMIM 605209
CCDS CCDS53849 CCDS31937 CCDS53847 CCDS53848
HPRD
IMGT
EMBL AC073911 AC127070 AF170724 AK001658 AK027687 AK302785 AK304333 AL137561 BC012072
GenPept AAF91084 AAH12072 BAA91817 BAB55297 BAG63989 BAG65178 CAB70812
RNA Seq Atlas 102723386 55743

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca