Version 5.4
Homo sapiens Protein: SHB
Summary
InnateDB Protein IDBP-66133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHB
Protein Name Src homology 2 domain containing adaptor protein B
Synonyms bA3J10.2;
Species Homo sapiens
Ensembl Protein ENSP00000366936
InnateDB Gene IDBG-66131 (SHB)
Protein Structure
UniProt Annotation
Function Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269PubMed:10828022, ECO:0000269PubMed:10837138, ECO:0000269PubMed:12084069, ECO:0000269PubMed:12464388, ECO:0000269PubMed:12520086, ECO:0000269PubMed:15026417, ECO:0000269PubMed:15919073, ECO:0000269PubMed:8806685, ECO:0000269PubMed:9484780, ECO:0000269PubMed:9751119}.
Subcellular Localization Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:9484780}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0009967 positive regulation of signal transduction
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
PFAM PF00017
PF14633
PRINTS PR00401
PIRSF
SMART SM00252
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15464
PhosphoSite PhosphoSite-Q15464
TrEMBL
UniProt Splice Variant
Entrez Gene 6461
UniGene Hs.521482
RefSeq NP_003019
HUGO HGNC:10838
OMIM 600314
CCDS CCDS43806
HPRD 02635
IMGT
EMBL AL138752 AL161448 AL583849 BC094765 BC136581 BC136582 CH471071 X75342
GenPept AAH94765 AAI36582 AAI36583 CAA53091 CAH73120 CAH73192 CAI13876 EAW58254 EAW58255

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca