Version 5.4
Homo sapiens Protein: LRRC16A
Summary
InnateDB Protein IDBP-66156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRC16A
Protein Name leucine rich repeat containing 16A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000331983
InnateDB Gene IDBG-66152 (LRRC16A)
Protein Structure
UniProt Annotation
Function Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity). May control actin dynamics in lamellipodia. Required for cell migration. {ECO:0000250, ECO:0000269PubMed:16054028, ECO:0000269PubMed:19846667}.
Subcellular Localization Cell projection, lamellipodium {ECO:0000269PubMed:19846667}. Cytoplasm {ECO:0000269PubMed:19846667}. Note=Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers. Also found on macropinosomes.
Disease Associations
Tissue Specificity Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney. {ECO:0000269PubMed:16054028}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0032403 protein complex binding
Biological Process
GO:0007015 actin filament organization
GO:0007596 blood coagulation
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030335 positive regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0031529 ruffle organization
GO:0046415 urate metabolic process
GO:0051496 positive regulation of stress fiber assembly
GO:0051638 barbed-end actin filament uncapping
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1902745 positive regulation of lamellipodium organization
GO:2000813 negative regulation of barbed-end actin filament capping
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030027 lamellipodium
GO:0031941 filamentous actin
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
PFAM
PRINTS
PIRSF
SMART SM00368
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5VZK9
PhosphoSite PhosphoSite-Q5VZK9
TrEMBL
UniProt Splice Variant
Entrez Gene 55604
UniGene Hs.649550
RefSeq NP_060110
HUGO HGNC:21581
OMIM 609593
CCDS CCDS54973
HPRD 11285
IMGT
EMBL AK000055 AK123817 AK125696 AL022170 AL024509 AL160037 FJ009082
GenPept ACI49709 BAA90912 BAC85701 BAC86250 CAH72024 CAI21583 CAI21665

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca