Version 5.4
Homo sapiens Protein: PRCP
Summary
InnateDB Protein IDBP-66179.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRCP
Protein Name prolylcarboxypeptidase (angiotensinase C)
Synonyms HUMPCP; PCP;
Species Homo sapiens
Ensembl Protein ENSP00000317362
InnateDB Gene IDBG-66177 (PRCP)
Protein Structure
UniProt Annotation
Function Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Subcellular Localization Lysosome.
Disease Associations
Tissue Specificity Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 12 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004185 serine-type carboxypeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR008758 Peptidase S28
IPR008761 Peptidase S37, tripeptidyl aminopeptidase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF05577
PF05576
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P42785
PhosphoSite PhosphoSite-P42785
TrEMBL E9PR42
UniProt Splice Variant
Entrez Gene 5547
UniGene Hs.706856
RefSeq NP_005031
HUGO HGNC:9344
OMIM 176785
CCDS CCDS8262
HPRD 08352
IMGT
EMBL AB451270 AB451397 AK090847 AK091786 AK302386 AK312919 AP000893 AP001646 BC001500 CH471076 L13977
GenPept AAA99891 AAH01500 BAG35764 BAG52238 BAG52417 BAG70084 BAG70211 BAH13692 EAW75074 EAW75075 EAW75076

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca