Version 5.4
Homo sapiens Gene: PRCP
Summary
InnateDB Gene IDBG-66177.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRCP
Gene Name prolylcarboxypeptidase (angiotensinase C)
Synonyms HUMPCP; PCP
Species Homo sapiens
Ensembl Gene ENSG00000137509
Encoded Proteins
IDBP-66179
prolylcarboxypeptidase (angiotensinase C)
IDBP-243688
prolylcarboxypeptidase (angiotensinase C)
IDBP-586177
prolylcarboxypeptidase (angiotensinase C)
IDBP-599440
prolylcarboxypeptidase (angiotensinase C)
IDBP-588595
prolylcarboxypeptidase (angiotensinase C)
IDBP-589943
prolylcarboxypeptidase (angiotensinase C)
IDBP-599587
prolylcarboxypeptidase (angiotensinase C)
IDBP-583676
prolylcarboxypeptidase (angiotensinase C)
IDBP-586190
prolylcarboxypeptidase (angiotensinase C)
IDBP-587860
prolylcarboxypeptidase (angiotensinase C)
IDBP-593020
prolylcarboxypeptidase (angiotensinase C)
IDBP-594477
prolylcarboxypeptidase (angiotensinase C)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:82823502-82970584
Strand Reverse strand
Band q14.1
Transcripts
ENST00000313010 ENSP00000317362
ENST00000393399 ENSP00000377055
ENST00000532709
ENST00000525772
ENST00000524642
ENST00000526918
ENST00000531283
ENST00000532476
ENST00000531801 ENSP00000432004
ENST00000534631 ENSP00000431559
ENST00000527444 ENSP00000436141
ENST00000531128 ENSP00000431435
ENST00000534396 ENSP00000432506
ENST00000529671 ENSP00000434771
ENST00000528082 ENSP00000435071
ENST00000532809 ENSP00000437169
ENST00000533126 ENSP00000431496
ENST00000534264 ENSP00000436095
ENST00000623464
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 12 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004185 serine-type carboxypeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0002155 regulation of thyroid hormone mediated signaling pathway
GO:0002353 plasma kallikrein-kinin cascade
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0042593 glucose homeostasis
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0060055 angiogenesis involved in wound healing
GO:0097009 energy homeostasis
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0045178 basal part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061119
View Gene Order
ENSBTAG00000033731
Not yet available
Pathways
NETPATH
REACTOME
REACT_326
Intrinsic Pathway pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_604
Hemostasis pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt P42785
TrEMBL A0A024R5L0 B3KR26 B7Z7Q6 E9PIG4 E9PKN6 E9PL49 E9PL85 E9PLY4 E9PNF7 E9PNJ1 E9PQB5 E9PQN3 E9PR42
UniProt Splice Variant
Entrez Gene 5547
UniGene Hs.523936 Hs.706856
RefSeq NM_005040 NM_199418 XM_005274093
HUGO HGNC:9344
OMIM 176785
CCDS CCDS41695 CCDS8262
HPRD
IMGT
EMBL AB451270 AB451397 AK090847 AK091786 AK302386 AK312919 AP000893 AP001646 BC001500 CH471076 L13977
GenPept AAA99891 AAH01500 BAG35764 BAG52238 BAG52417 BAG70084 BAG70211 BAH13692 EAW75074 EAW75075 EAW75076
RNA Seq Atlas 5547

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca