Version 5.4
Homo sapiens Protein: ALDH1B1
Summary
InnateDB Protein IDBP-66263.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH1B1
Protein Name aldehyde dehydrogenase 1 family, member B1
Synonyms ALDH5; ALDHX;
Species Homo sapiens
Ensembl Protein ENSP00000366927
InnateDB Gene IDBG-66261 (ALDH1B1)
Protein Structure
UniProt Annotation
Function ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Subcellular Localization Mitochondrion matrix.
Disease Associations
Tissue Specificity Liver, testis and to a lesser extent in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006068 ethanol catabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase
PFAM PF00171
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30837
PhosphoSite PhosphoSite-P30837
TrEMBL B4DLJ0
UniProt Splice Variant
Entrez Gene 219
UniGene Hs.743532
RefSeq NP_000683
HUGO HGNC:407
OMIM 100670
CCDS CCDS6615
HPRD 00005
IMGT
EMBL AK297020 AK313344 AL135785 BC001619 BT007418 M63967
GenPept AAA96830 AAH01619 AAP36086 BAG36147 BAG59552 CAD13246

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca