InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF268

Summary

InnateDB Protein

IDBP-66281.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF268

Protein Name

zinc finger protein 268

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000228289

InnateDB Gene

IDBG-66258 (ZNF268)

Protein Structure

UniProt Annotation

Function

Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.

Subcellular Localization

Isoform 1: Nucleus {ECO:0000269PubMed:23665872}.Isoform 2: Nucleus {ECO:0000269PubMed:23665872}. Cytoplasm {ECO:0000269PubMed:23665872}.

Disease Associations

Tissue Specificity

Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells. {ECO:0000269PubMed:12200376, ECO:0000269PubMed:16735226, ECO:0000269PubMed:16865230, ECO:0000269PubMed:18949428, ECO:0000269PubMed:23091055, ECO:0000269PubMed:23946776}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001934	positive regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007346	regulation of mitotic cell cycle
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008588	release of cytoplasmic sequestered NF-kappaB
GO:0030154	cell differentiation
GO:0030335	positive regulation of cell migration
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043497	regulation of protein heterodimerization activity
GO:0045597	positive regulation of cell differentiation
GO:0045732	positive regulation of protein catabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046022	positive regulation of transcription from RNA polymerase II promoter during mitosis
GO:0071157	negative regulation of cell cycle arrest
GO:0071356	cellular response to tumor necrosis factor
GO:0090073	positive regulation of protein homodimerization activity