Version 5.4
Homo sapiens Protein: CARD10
Summary
InnateDB Protein IDBP-6634.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARD10
Protein Name caspase recruitment domain family, member 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000251973
InnateDB Gene IDBG-6632 (CARD10)
Protein Structure
UniProt Annotation
Function Activates NF-kappa-B via BCL10 and IKK.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030159 receptor signaling complex scaffold activity
Biological Process
GO:0006461 protein complex assembly
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0042981 regulation of apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0032449 CBM complex
Protein Structure and Domains
PDB ID
InterPro IPR001315 CARD domain
IPR011029 Death-like domain
PFAM PF00619
PRINTS
PIRSF
SMART SM00114
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BWT7
PhosphoSite PhosphoSite-Q9BWT7
TrEMBL Q17RA1
UniProt Splice Variant
Entrez Gene 29775
UniGene Hs.739716
RefSeq NP_055365
HUGO HGNC:16422
OMIM 607209
CCDS CCDS13948
HPRD 06233
IMGT
EMBL AK296176 AL022315 AL049851 AY028896 AY032928 BC113659 BC117403 FP325335
GenPept AAI13660 AAI17404 AAK26165 AAK54454 BAH12273 CAI19345

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca