InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BPIFB1

Summary

InnateDB Protein

IDBP-66371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BPIFB1

Protein Name

BPI fold containing family B, member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000253354

InnateDB Gene

IDBG-66369 (BPIFB1)

Protein Structure

UniProt Annotation

Function

May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. {ECO:0000269PubMed:21900486}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in duodenum mucosal crypts of cholera patients, near Paneth cells (at protein level). Detected in trachea, nasal septal epithelium and lung. {ECO:0000269PubMed:21900486}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008289	lipid binding

Biological Process

GO:0002227	innate immune response in mucosa
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
IPR021193 PLUNC, long form

PFAM

PF02886
PF01273

PRINTS

PIRSF

PIRSF037186

SMART

SM00329
SM00328

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt