Version 5.4
Homo sapiens Gene: BPIFB1
Summary
InnateDB Gene IDBG-66369.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BPIFB1
Gene Name BPI fold containing family B, member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125999
Encoded Proteins
IDBP-66371
BPI fold containing family B, member 1
IDBP-371705
BPI fold containing family B, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:33273480-33309878
Strand Forward strand
Band q11.21
Transcripts
ENST00000253354 ENSP00000253354
ENST00000423645 ENSP00000390471
ENST00000464032
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008289 lipid binding
Biological Process
GO:0002227 innate immune response in mucosa
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027485
View Gene Order
ENSBTAG00000015724
Not yet available
Cross-References
SwissProt Q8TDL5
TrEMBL A2A2R0
UniProt Splice Variant
Entrez Gene 92747
UniGene
RefSeq NM_033197
HUGO HGNC:16108
OMIM
CCDS CCDS13218
HPRD
IMGT
EMBL AF364078 AK127971 AK290243 AL121901 AL355392 AY358595 BC008429
GenPept AAH08429 AAM00283 AAQ88958 BAC87212 BAF82932 CAI14743 CAI19398
RNA Seq Atlas 92747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca