InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCHFR

Summary

InnateDB Protein

IDBP-6647.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCHFR

Protein Name

GTP cyclohydrolase I feedback regulator

Synonyms

GFRP; HsT16933; P35;

Species

Homo sapiens

Ensembl Protein

ENSP00000260447

InnateDB Gene

IDBG-6645 (GCHFR)

Protein Structure

UniProt Annotation

Function

Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. {ECO:0000269PubMed:16778797}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16778797}. Nucleus membrane {ECO:0000269PubMed:16778797}. Cytoplasm, cytosol {ECO:0000269PubMed:16778797}.

Disease Associations

Tissue Specificity

In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). {ECO:0000269PubMed:16778797}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0016597	amino acid binding
GO:0016787	hydrolase activity
GO:0019899	enzyme binding
GO:0030742	GTP-dependent protein binding
GO:0044549	GTP cyclohydrolase binding

Biological Process

GO:0006461	protein complex assembly
GO:0006809	nitric oxide biosynthetic process
GO:0008152	metabolic process
GO:0009890	negative regulation of biosynthetic process
GO:0042133	neurotransmitter metabolic process
GO:0043105	negative regulation of GTP cyclohydrolase I activity
GO:0044281	small molecule metabolic process
GO:0046209	nitric oxide metabolic process
GO:0050999	regulation of nitric-oxide synthase activity
GO:0051291	protein heterooligomerization