InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GCHFR

Summary

InnateDB Gene

IDBG-6645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCHFR

Gene Name

GTP cyclohydrolase I feedback regulator

Synonyms

GFRP; HsT16933; P35

Species

Homo sapiens

Ensembl Gene

ENSG00000137880

Encoded Proteins

IDBP-6647

GTP cyclohydrolase I feedback regulator

IDBP-586611

GTP cyclohydrolase I feedback regulator

IDBP-811704

GTP cyclohydrolase I feedback regulator

IDBP-591095

GTP cyclohydrolase I feedback regulator

IDBP-585058

GTP cyclohydrolase I feedback regulator

IDBP-591055

GTP cyclohydrolase I feedback regulator

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:40764020-40767710

Strand

Forward strand

Band

q15.1

Transcripts

ENST00000260447	ENSP00000260447
ENST00000561160	ENSP00000454067
ENST00000558670	ENSP00000477896
ENST00000559445	ENSP00000453871
ENST00000559932	ENSP00000454195
ENST00000558467	ENSP00000453640

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0016597	amino acid binding
GO:0016787	hydrolase activity
GO:0019899	enzyme binding
GO:0030742	GTP-dependent protein binding
GO:0044549	GTP cyclohydrolase binding

Biological Process

GO:0006461	protein complex assembly
GO:0006809	nitric oxide biosynthetic process
GO:0008152	metabolic process
GO:0009890	negative regulation of biosynthetic process
GO:0042133	neurotransmitter metabolic process
GO:0043105	negative regulation of GTP cyclohydrolase I activity
GO:0044281	small molecule metabolic process
GO:0046209	nitric oxide metabolic process
GO:0050999	regulation of nitric-oxide synthase activity
GO:0051291	protein heterooligomerization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030425	dendrite
GO:0031965	nuclear membrane
GO:0042470	melanosome
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000046814

View Gene Order

ENSBTAG00000013477

Not yet available

Pathways

NETPATH

REACTOME

REACT_111176

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway

REACT_12389

eNOS activation and regulation pathway

REACT_12508

Metabolism of nitric oxide pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H0YNX7

UniProt Splice Variant

Entrez Gene

2644

UniGene

RefSeq

NM_005258

HUGO

HGNC:4194

OMIM

602437

CCDS

CCDS10064

HPRD

03895

IMGT

EMBL

AC012476 CH471125

GenPept

EAW92442

RNA Seq Atlas

2644