InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYTL2

Summary

InnateDB Protein

IDBP-66499.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYTL2

Protein Name

synaptotagmin-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000318803

InnateDB Gene

IDBG-66497 (SYTL2)

Protein Structure

UniProt Annotation

Function

Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269PubMed:17182843, ECO:0000269PubMed:18266782, ECO:0000269PubMed:18812475}.

Subcellular Localization

Isoform 1: Cytoplasm. Cell membrane. Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A.Isoform 4: Cell membrane. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells. {ECO:0000269PubMed:17182843, ECO:0000269PubMed:18266782, ECO:0000269PubMed:18812475}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0017137	Rab GTPase binding
GO:0019902	phosphatase binding
GO:0042043	neurexin family protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0006904	vesicle docking involved in exocytosis
GO:0010923	negative regulation of phosphatase activity
GO:0016192	vesicle-mediated transport
GO:0070257	positive regulation of mucus secretion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0019897	extrinsic component of plasma membrane
GO:0042470	melanosome
GO:0070382	exocytic vesicle