Version 5.4
Homo sapiens Protein: FXR1
Summary
InnateDB Protein IDBP-66611.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FXR1
Protein Name fragile X mental retardation, autosomal homolog 1
Synonyms FXR1P;
Species Homo sapiens
Ensembl Protein ENSP00000307633
InnateDB Gene IDBG-66609 (FXR1)
Protein Structure
UniProt Annotation
Function RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:7781595}.
Disease Associations
Tissue Specificity Expressed in all tissues examined including heart, brain, kidney and testis. {ECO:0000269PubMed:7781595}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 42 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006915 apoptotic process
GO:0007517 muscle organ development
GO:0030154 cell differentiation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
IPR022034 Fragile X mental retardation protein family
PFAM PF00013
PF13014
PF12235
PRINTS
PIRSF
SMART SM00322
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51114
PhosphoSite PhosphoSite-P51114
TrEMBL C9JZE0
UniProt Splice Variant
Entrez Gene 8087
UniGene Hs.478407
RefSeq NP_001013457
HUGO HGNC:4023
OMIM 600819
CCDS CCDS33894
HPRD 02892
IMGT
EMBL AC008009 AC068638 AC108734 AK292633 AY341428 BC028983 U25165
GenPept AAC50155 AAH28983 AAQ20045 BAF85322

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca