InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FXR1

Summary

InnateDB Gene

IDBG-66609.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FXR1

Gene Name

fragile X mental retardation, autosomal homolog 1

Synonyms

FXR1P

Species

Homo sapiens

Ensembl Gene

ENSG00000114416

Encoded Proteins

IDBP-66611

fragile X mental retardation, autosomal homolog 1

IDBP-66613

fragile X mental retardation, autosomal homolog 1

IDBP-385709

fragile X mental retardation, autosomal homolog 1

IDBP-484507

fragile X mental retardation, autosomal homolog 1

IDBP-484583

fragile X mental retardation, autosomal homolog 1

IDBP-474110

fragile X mental retardation, autosomal homolog 1

IDBP-485118

fragile X mental retardation, autosomal homolog 1

IDBP-477692

fragile X mental retardation, autosomal homolog 1

IDBP-482810

fragile X mental retardation, autosomal homolog 1

IDBP-480424

fragile X mental retardation, autosomal homolog 1

IDBP-475303

fragile X mental retardation, autosomal homolog 1

IDBP-475178

fragile X mental retardation, autosomal homolog 1

IDBP-479322

fragile X mental retardation, autosomal homolog 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19864602

FXR1 is an essential component of a network of nuclear receptors that regulate intestinal innate immunity and homeostasis.

Entrez Gene

Summary

The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:180868141-180982753

Strand

Forward strand

Band

q26.33

Transcripts

ENST00000305586	ENSP00000307633
ENST00000357559	ENSP00000350170
ENST00000445140	ENSP00000388828
ENST00000469882	ENSP00000419793
ENST00000484790	ENSP00000417125
ENST00000465551	ENSP00000418724
ENST00000475315
ENST00000491674	ENSP00000419047
ENST00000491062	ENSP00000420643
ENST00000468861	ENSP00000420515
ENST00000479176
ENST00000472339
ENST00000484958	ENSP00000419933
ENST00000480918	ENSP00000418097
ENST00000484042	ENSP00000417513
ENST00000461801
ENST00000473375
ENST00000461044
ENST00000498658
ENST00000476672
ENST00000482125	ENSP00000418027
ENST00000481383

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	42 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002151	G-quadruplex RNA binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006915	apoptotic process
GO:0007517	muscle organ development
GO:0017148	negative regulation of translation
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005844	polysome
GO:0016020	membrane
GO:0043034	costamere

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027680

View Gene Order

ENSBTAG00000016457

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa03013

RNA transport pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.478407

RefSeq

NM_001013438 NM_001013439 NM_005087

HUGO

OMIM

CCDS

CCDS3238 CCDS33894 CCDS46965

HPRD

02892

IMGT

EMBL

GenPept

RNA Seq Atlas