InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FXR1

Summary

InnateDB Protein

IDBP-66613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FXR1

Protein Name

fragile X mental retardation, autosomal homolog 1

Synonyms

FXR1P;

Species

Homo sapiens

Ensembl Protein

ENSP00000350170

InnateDB Gene

IDBG-66609 (FXR1)

Protein Structure

UniProt Annotation

Function

RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:7781595}.

Disease Associations

Tissue Specificity

Expressed in all tissues examined including heart, brain, kidney and testis. {ECO:0000269PubMed:7781595}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	42 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002151	G-quadruplex RNA binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006915	apoptotic process
GO:0007517	muscle organ development
GO:0017148	negative regulation of translation
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005844	polysome
GO:0016020	membrane
GO:0043034	costamere

Protein Structure and Domains

PDB ID

InterPro

IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
IPR008395 Agenet-like domain
IPR012340 Nucleic acid-binding, OB-fold
IPR022034 Fragile X mental retardation protein family

PFAM

PF00013
PF13014
PF05641
PF12235

PRINTS

PIRSF

SMART

SM00322

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51114