InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM38

Summary

InnateDB Protein

IDBP-66677.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM38

Protein Name

tripartite motif containing 38

Synonyms

RNF15; RORET;

Species

Homo sapiens

Ensembl Protein

ENSP00000349596

InnateDB Gene

IDBG-66673 (TRIM38)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0007165	signal transduction
GO:0032648	regulation of interferon-beta production
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045070	positive regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0046598	positive regulation of viral entry into host cell
GO:0050687	negative regulation of defense response to virus
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070936	protein K48-linked ubiquitination

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00643
PF13639
PF14634
PF00622
PF13765

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00184
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt