Version 5.4
Homo sapiens Gene: TRIM38
Summary
InnateDB Gene IDBG-66673.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM38
Gene Name tripartite motif containing 38
Synonyms RNF15; RORET
Species Homo sapiens
Ensembl Gene ENSG00000112343
Encoded Proteins
IDBP-66677
tripartite motif containing 38
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23056470
TRIM38 targets TICAM1 (TRIF) for degradation to negatively regulateTLR3-mediated IFNB signalling.
PMID 23438823
TRIM38 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:25962802-25987156
Strand Forward strand
Band p22.2
Transcripts
ENST00000357085 ENSP00000349596
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0007165 signal transduction
GO:0032648 regulation of interferon-beta production
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045070 positive regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0046598 positive regulation of viral entry into host cell
GO:0050687 negative regulation of defense response to virus
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000064140
View Gene Order
ENSBTAG00000018523
Not yet available
Cross-References
SwissProt O00635
TrEMBL A0A024QZY4
UniProt Splice Variant
Entrez Gene 10475
UniGene Hs.584851 Hs.597352
RefSeq NM_006355 XM_005248799 XM_005248800
HUGO HGNC:10059
OMIM
CCDS CCDS4568
HPRD
IMGT
EMBL BC026930 CH471087 U90547 U91328
GenPept AAB53425 AAB82084 AAH26930 EAW55501 EAW55502 EAW55504 EAW55505
RNA Seq Atlas 10475

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca