Version 5.4
| Homo sapiens Protein: IL36RN | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-66763.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | IL36RN | ||||||||||||||||||
| Protein Name | interleukin 36 receptor antagonist | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Protein | ENSP00000259212 | ||||||||||||||||||
| InnateDB Gene | IDBG-66761 (IL36RN) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | Is a highly and a specific antagonist of the IL-1 receptor-related protein 2/IL1RL2-mediated response to interleukin IL36G. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response. | ||||||||||||||||||
| Subcellular Localization | Secreted. | ||||||||||||||||||
| Disease Associations | Psoriasis generalized pustular (PSORP) [MIM:614204]: A life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C- reactive protein. {ECO:0000269PubMed:21839423, ECO:0000269PubMed:21848462, ECO:0000269PubMed:22903787}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||
| Tissue Specificity | Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. | ||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR000975
Interleukin-1 family IPR003294 Interleukin-1 alpha/beta IPR003297 Interleukin-1 receptor antagonist / Interleukin-36 IPR008996 Cytokine, IL-1-like |
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| PFAM |
PF00340
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| PRINTS |
PR00264
PR01357 PR01360 |
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| PIRSF | |||||||||||||||||||
| SMART | |||||||||||||||||||
| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9UBH0 | ||||||||||||||||||
| PhosphoSite | PhosphoSite-Q9UBH0 | ||||||||||||||||||
| TrEMBL | C9JTH1 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 26525 | ||||||||||||||||||
| UniGene | Hs.516301 | ||||||||||||||||||
| RefSeq | NP_775262 | ||||||||||||||||||
| HUGO | HGNC:15561 | ||||||||||||||||||
| OMIM | 605507 | ||||||||||||||||||
| CCDS | CCDS2111 | ||||||||||||||||||
| HPRD | 16112 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC016724 AF186094 AF201830 AF216693 AF230377 AJ242737 AJ242738 AJ271338 AK290249 AY359117 AY972853 BC024747 BN000002 CH471217 | ||||||||||||||||||
| GenPept | AAF02757 AAF25210 AAF76981 AAF91274 AAH24747 AAQ89475 AAX59031 AAY14990 BAF82938 CAB59822 CAB59823 CAB67704 CAD29877 EAW73617 EAW73618 | ||||||||||||||||||