Homo sapiens Gene: IL36RN
Summary
InnateDB Gene IDBG-66761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL36RN
Gene Name interleukin 36 receptor antagonist
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136695
Encoded Proteins
interleukin 36 receptor antagonist
interleukin 36 receptor antagonist
interleukin 36 receptor antagonist
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:113058638-113065382
Strand Forward strand
Band q14.1
Transcripts
ENST00000346807 ENSP00000259212
ENST00000393200 ENSP00000376896
ENST00000437409 ENSP00000409262
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
GO:0005152 interleukin-1 receptor antagonist activity
Biological Process
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0032715 negative regulation of interleukin-6 production
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q9UBH0
TrEMBL A0A024R518 C9JTH1
UniProt Splice Variant
Entrez Gene 26525
UniGene Hs.516301
RefSeq NM_012275 NM_173170 XM_005263638
HUGO HGNC:15561
OMIM 605507
CCDS CCDS2111
HPRD
IMGT
EMBL AC016724 AF186094 AF201830 AF216693 AF230377 AJ242737 AJ242738 AJ271338 AK290249 AY359117 AY972853 BC024747 BN000002 CH471217
GenPept AAF02757 AAF25210 AAF76981 AAF91274 AAH24747 AAQ89475 AAX59031 AAY14990 BAF82938 CAB59822 CAB59823 CAB67704 CAD29877 EAW73617 EAW73618
RNA Seq Atlas 26525