Version 5.4
Homo sapiens Protein: CDC42EP4
Summary
InnateDB Protein IDBP-66852.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42EP4
Protein Name CDC42 effector protein (Rho GTPase binding) 4
Synonyms BORG4; CEP4; KAIA1777;
Species Homo sapiens
Ensembl Protein ENSP00000338258
InnateDB Gene IDBG-66850 (CDC42EP4)
Protein Structure
UniProt Annotation
Function Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.
Subcellular Localization Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Disease Associations
Tissue Specificity Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007266 Rho protein signal transduction
GO:0008360 regulation of cell shape
GO:0031274 positive regulation of pseudopodium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR000095 CRIB domain
PFAM PF00786
PRINTS
PIRSF
SMART SM00285
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H3Q1
PhosphoSite PhosphoSite-Q9H3Q1
TrEMBL J3QQS6
UniProt Splice Variant
Entrez Gene 23580
UniGene Hs.3903
RefSeq NP_036253
HUGO HGNC:17147
OMIM 605468
CCDS CCDS11695
HPRD 08383
IMGT
EMBL AB042237 AC087301 AF099664 AK027385 AK312536 BC002774 BC010451 CH471099
GenPept AAD16299 AAH02774 AAH10451 BAB17272 BAG35435 BAG51313 EAW89123 EAW89124

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca