InnateDB Protein
|
IDBP-67131.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PARL
|
Protein Name
|
presenilin associated, rhomboid-like
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000325421
|
InnateDB Gene
|
IDBG-67129 (PARL)
|
Protein Structure
|
|
Function |
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. {ECO:0000250, ECO:0000269PubMed:14732705, ECO:0000269PubMed:17116872}.
|
Subcellular Localization |
Mitochondrion inner membrane {ECO:0000269PubMed:17116872}; Multi-pass membrane protein {ECO:0000269PubMed:17116872}.P-beta: Nucleus. Note=Translocated into the nucleus by an unknown mechanism.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0004252
|
serine-type endopeptidase activity
|
|
Biological Process |
GO:0006508
|
proteolysis
|
GO:0090201
|
negative regulation of release of cytochrome c from mitochondria
|
GO:2001243
|
negative regulation of intrinsic apoptotic signaling pathway
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR022764
Peptidase S54, rhomboid domain
|
PFAM |
PF01694
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9H300
|
PhosphoSite |
PhosphoSite-Q9H300
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
55486
|
UniGene |
Hs.478469
|
RefSeq |
NP_061092
|
HUGO |
HGNC:18253
|
OMIM |
607858
|
CCDS |
CCDS3248
|
HPRD |
08484
|
IMGT |
|
EMBL |
AF116692
AF197937
BC003653
BC014058
|
GenPept |
AAF71112
AAG28519
AAH03653
AAH14058
|
|
|