Version 5.4
Homo sapiens Gene: PARL
Summary
InnateDB Gene IDBG-67129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARL
Gene Name presenilin associated, rhomboid-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000175193
Encoded Proteins
IDBP-67131
presenilin associated, rhomboid-like
IDBP-67133
presenilin associated, rhomboid-like
IDBP-385789
presenilin associated, rhomboid-like
IDBP-385791
presenilin associated, rhomboid-like
IDBP-385792
presenilin associated, rhomboid-like
IDBP-385795
presenilin associated, rhomboid-like
IDBP-385796
presenilin associated, rhomboid-like
IDBP-385798
presenilin associated, rhomboid-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:183829385-183884933
Strand Reverse strand
Band q27.1
Transcripts
ENST00000317096 ENSP00000325421
ENST00000311101 ENSP00000310676
ENST00000417784 ENSP00000398043
ENST00000450375 ENSP00000402689
ENST00000418450 ENSP00000392926
ENST00000435888 ENSP00000402137
ENST00000421484 ENSP00000404421
ENST00000449306 ENSP00000396691
ENST00000488202
ENST00000469056
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033918
View Gene Order
ENSBTAG00000014460
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.478469
RefSeq NM_001037639 NM_018622
HUGO
OMIM
CCDS CCDS3248 CCDS33897
HPRD 08484
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca