Version 5.4
Homo sapiens Protein: PARL
Summary
InnateDB Protein IDBP-67133.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARL
Protein Name presenilin associated, rhomboid-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000310676
InnateDB Gene IDBG-67129 (PARL)
Protein Structure
UniProt Annotation
Function Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. {ECO:0000250, ECO:0000269PubMed:14732705, ECO:0000269PubMed:17116872}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:17116872}; Multi-pass membrane protein {ECO:0000269PubMed:17116872}.P-beta: Nucleus. Note=Translocated into the nucleus by an unknown mechanism.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR022764 Peptidase S54, rhomboid domain
PFAM PF01694
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H300
PhosphoSite PhosphoSite-Q9H300
TrEMBL
UniProt Splice Variant
Entrez Gene 55486
UniGene Hs.478469
RefSeq NP_001032728
HUGO HGNC:18253
OMIM 607858
CCDS CCDS33897
HPRD 08484
IMGT
EMBL AF116692 AF197937 BC003653 BC014058
GenPept AAF71112 AAG28519 AAH03653 AAH14058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca