InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRM5

Summary

InnateDB Protein

IDBP-67200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRM5

Protein Name

glutamate receptor, metabotropic 5

Synonyms

GPRC1E; mGlu5; MGLUR5; PPP1R86;

Species

Homo sapiens

Ensembl Protein

ENSP00000306138

InnateDB Gene

IDBG-67198 (GRM5)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. {ECO:0000269PubMed:7908515, ECO:0000269Ref.7}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:7908515, ECO:0000269Ref.7}; Multi-pass membrane protein {ECO:0000269PubMed:7908515, ECO:0000269Ref.7}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0031687	A2A adenosine receptor binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007612	learning
GO:0007626	locomotory behavior
GO:0040013	negative regulation of locomotion
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048170	positive regulation of long-term neuronal synaptic plasticity
GO:0050890	cognition
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0070062	extracellular vesicular exosome
GO:0097449	astrocyte projection

Protein Structure and Domains

PDB ID

InterPro

IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000202 GPCR, family 3, metabotropic glutamate receptor 5
IPR000337 GPCR, family 3
IPR001256 GPCR, family 3, metabotropic glutamate receptor 1
IPR001828 Extracellular ligand-binding receptor
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR019588 Metabotropic glutamate receptor, Homer-binding domain
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003
PF10606

PRINTS

PR00593
PR01055
PR00248
PR01051

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P41594