InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRM5

Summary

InnateDB Gene

IDBG-67198.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRM5

Gene Name

glutamate receptor, metabotropic 5

Synonyms

GPRC1E; mGlu5; MGLUR5; PPP1R86

Species

Homo sapiens

Ensembl Gene

ENSG00000168959

Encoded Proteins

IDBP-67200

glutamate receptor, metabotropic 5

IDBP-67202

glutamate receptor, metabotropic 5

IDBP-243910

glutamate receptor, metabotropic 5

IDBP-381947

glutamate receptor, metabotropic 5

IDBP-381951

glutamate receptor, metabotropic 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:88504576-89065945

Strand

Reverse strand

Band

q14.3

Transcripts

ENST00000305447	ENSP00000306138
ENST00000305432	ENSP00000305905
ENST00000393294	ENSP00000376972
ENST00000455756	ENSP00000405690
ENST00000449371	ENSP00000403724

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity
GO:0031687	A2A adenosine receptor binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007612	learning
GO:0007626	locomotory behavior
GO:0040013	negative regulation of locomotion
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048170	positive regulation of long-term neuronal synaptic plasticity
GO:0050890	cognition
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0070062	extracellular vesicular exosome
GO:0097449	astrocyte projection

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000049583

View Gene Order

ENSBTAG00000048061

Not yet available

Pathways

NETPATH

REACTOME

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_18319

Class C/3 (Metabotropic glutamate/pheromone receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04540

Gap junction pathway

hsa04720

Long-term potentiation pathway

hsa04020

Calcium signaling pathway pathway

hsa05016

Huntington's disease pathway

INOH

INOH website

GPCR GroupI metabotropic glutamate receptor signaling pathway pathway

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.147361 Hs.668029

RefSeq

NM_000842 NM_001143831 XM_006718828 XM_006718829 XM_006718830

HUGO

OMIM

CCDS

CCDS44694 CCDS8283

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas