InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP12

Summary

InnateDB Protein

IDBP-67227.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP12

Protein Name

Rho GTPase activating protein 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364399

InnateDB Gene

IDBG-67225 (ARHGAP12)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0002011	morphogenesis of an epithelial sheet
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001202 WW domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein

PFAM

PF00620
PF00397
PF00018
PF14604
PF00169

PRINTS

PR00452

PIRSF

SMART

SM00324
SM00456
SM00326
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt